CNST

Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]). [supplied by OMIM, Jun 2010]

Description

Consortin, connexin sorting protein

Tissue specificity

Low tissue specificity

Subcell location

Vesicles

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (246566444 - 246668595)

Ensembl ID

ENSG00000162852  (ver. 103.38)

Orthologs

Mouse Cnst: ENSMUSG00000038949

UniProt

Q6PJW8

neXtProt

NX_Q6PJW8

Human splice variants
Mouse splice variants

Protein structure