PPP1R12B

Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]

Description

Protein phosphatase 1 regulatory subunit 12B

Tissue specificity

Tissue enhanced (heart muscle)

Subcell location

Plasma membrane, Actin filaments

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (202348699 - 202592706)

Ensembl ID

ENSG00000077157  (ver. 103.38)

Orthologs

Mouse Ppp1r12b: ENSMUSG00000073557

UniProt

O60237

neXtProt

NX_O60237

Human splice variants
Mouse splice variants

Protein structure