ARID4B

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Description

AT-rich interaction domain 4B

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Mitochondria, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

1 (235131634 - 235328219)

Ensembl ID

ENSG00000054267  (ver. 103.38)

Orthologs

Mouse Arid4b: ENSMUSG00000039219

UniProt

Q4LE39

neXtProt

NX_Q4LE39

Human splice variants
Mouse splice variants

Protein structure