DNAJC21

This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the precursor 45S ribosomal RNA and may be involved in early nuclear ribosomal RNA biogenesis and maturation of the 60S ribosomal subunit. Mutations in this gene result in Bone marrow failure syndrome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2017]

Description

DnaJ heat shock protein family (Hsp40) member C21

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (34929559 - 34958964)

Ensembl ID

ENSG00000168724  (ver. 103.38)

Orthologs

Mouse Dnajc21: ENSMUSG00000044224

UniProt

Q5F1R6

neXtProt

NX_Q5F1R6

Human splice variants
Mouse splice variants

Protein structure