RGL4

This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. [provided by RefSeq, Jul 2016]

Description

Ral guanine nucleotide dissociation stimulator like 4

Tissue specificity

Tissue enriched (bone marrow)

Subcell location

Centrosome

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

22 (23688136 - 23699176)

Ensembl ID

ENSG00000159496  (ver. 103.38)

Orthologs

-

UniProt

Q8IZJ4

neXtProt

NX_Q8IZJ4

Human splice variants

Protein structure