SENP3

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]). [supplied by OMIM, Jun 2009]

Description

SUMO specific peptidase 3

Protein family

Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

17:p13.1 (7561919 - 7571969)

Ensembl ID

ENSG00000161956  (ver. 99.38)

Orthologs

-

UniProt

Q9H4L4

neXtProt

NX_Q9H4L4

Human splice variants