GRID2

gene product
GluD2, GluR-delta-2
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
109 antibodies from 24 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Invitrogen Antibodies
6 antibodies
antibodies-online
33 antibodies
GeneTex
2 antibodies
Affinity Biosciences
1 antibody
Boster Biological Technology
1 antibody
LifeSpan BioSciences, Inc.
8 antibodies
Biorbyt
10 antibodies
Novus Biologicals
4 antibodies
OriGene
2 antibodies
Bioworld Technology, Inc
1 antibody
Abgent
1 antibody
Aviva Systems Biology
1 antibody
NovoPro Bioscience Inc.
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
Acris Antibodies GmbH
1 antibody
Atlas Antibodies
2 antibodies
Abnova Corporation
2 antibodies
Creative Biolabs
10 antibodies
Creative Diagnostics
4 antibodies
St John's Laboratory
1 antibody
United States Biological
13 antibodies
MyBioSource
2 antibodies
Leading Biology
1 antibody
Sigma-Aldrich
1 antibody