SLITRK5

Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]). [supplied by OMIM, Mar 2008]

Description

SLIT and NTRK like family member 5

Tissue specificity

Tissue enhanced (brain, fallopian tube, salivary gland)

Subcell location

Vesicles

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

13 (87672615 - 87696272)

Ensembl ID

ENSG00000165300  (ver. 103.38)

Orthologs

Mouse Slitrk5: ENSMUSG00000033214

UniProt

O94991

neXtProt

NX_O94991

Human splice variants
Mouse splice variants

Protein structure