HCN4

This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]

Description

Hyperpolarization activated cyclic nucleotide gated potassium channel 4

Tissue specificity

Group enriched (brain, heart muscle, testis)

Predicted location

Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

15 (73319859 - 73368958)

Ensembl ID

ENSG00000138622  (ver. 103.38)

Orthologs

Mouse Hcn4: ENSMUSG00000032338

UniProt

Q9Y3Q4

neXtProt

NX_Q9Y3Q4

Human splice variants
Mouse splice variants

Protein structure