LPXN

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2009]

Description

Leupaxin

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Nuclear speckles, Focal adhesion sites, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (58526871 - 58578220)

Ensembl ID

ENSG00000110031  (ver. 103.38)

Orthologs

Mouse Lpxn: ENSMUSG00000024696

UniProt

O60711

neXtProt

NX_O60711

Human splice variants
Mouse splice variants

Protein structure