RANBP17

The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors. [supplied by OMIM, Jul 2002]

Description

RAN binding protein 17

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm, Nuclear membrane, Nuclear bodies, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

5 (170861870 - 171300015)

Ensembl ID

ENSG00000204764  (ver. 103.38)

Orthologs

Mouse Ranbp17: ENSMUSG00000040594

UniProt

Q9H2T7

neXtProt

NX_Q9H2T7

Human splice variants
Mouse splice variants

Protein structure