SEC62

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

Description

SEC62 homolog, preprotein translocation factor

Tissue specificity

Low tissue specificity

Subcell location

Endoplasmic reticulum, Intermediate filaments

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

3 (169966635 - 169998373)

Ensembl ID

ENSG00000008952  (ver. 103.38)

Orthologs

Mouse Sec62: ENSMUSG00000027706

UniProt

Q99442

neXtProt

NX_Q99442

Human splice variants
Mouse splice variants

Protein structure