FAR2

This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]

Description

Fatty acyl-CoA reductase 2

Tissue specificity

Tissue enhanced (epididymis, intestine)

Subcell location

Nucleoli, Golgi apparatus

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (29149103 - 29340980)

Ensembl ID

ENSG00000064763  (ver. 103.38)

Orthologs

Mouse Far2: ENSMUSG00000030303

UniProt

Q96K12

neXtProt

NX_Q96K12

Human splice variants
Mouse splice variants

Protein structure