MDGA1

This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six Ig-like domains, a single fibronectin type III domain, a MAM domain and a C-terminal GPI-anchoring site. Studies in other mammals suggest this protein plays a role in cell adhesion, migration, and axon guidance and, in the developing brain, neuronal migration. In humans, this gene is associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2016]

Description

MAM domain containing glycosylphosphatidylinositol anchor 1

Tissue specificity

Tissue enriched (brain)

Subcell location

Golgi apparatus, Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

6 (37630679 - 37699306)

Ensembl ID

ENSG00000112139  (ver. 103.38)

Orthologs

Mouse Mdga1: ENSMUSG00000043557

UniProt

Q8NFP4

neXtProt

NX_Q8NFP4

Human splice variants
Mouse splice variants

Protein structure