NTS

This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]

Description

Neurotensin

Tissue specificity

Tissue enriched (intestine)

Subcell location

Vesicles

Predicted location

Secreted to digestive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (85874295 - 85882992)

Ensembl ID

ENSG00000133636  (ver. 103.38)

Orthologs

Mouse Nts: ENSMUSG00000019890

UniProt

P30990

neXtProt

NX_P30990

Human splice variants
Mouse splice variants

Protein structure