SLC25A31

The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar cytoskeleton and with glycolytic enzymes. Male mice with mutations in the mouse ortholog of this gene are sterile and spermatocytes display an early meiotic arrest phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Description

Solute carrier family 25 member 31

Tissue specificity

Tissue enriched (testis)

Subcell location

Mitochondria

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

4 (127730400 - 127774292)

Ensembl ID

ENSG00000151475  (ver. 103.38)

Orthologs

Mouse Slc25a31: ENSMUSG00000069041

UniProt

Q9H0C2

neXtProt

NX_Q9H0C2

Human splice variants
Mouse splice variants

Protein structure