RHD

The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Rh blood group D antigen

Tissue specificity

Tissue enriched (bone marrow)

Subcell location

Nucleoplasm, Plasma membrane

Predicted location

Membrane

Protein family

Blood group antigen proteins
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

1 (25272393 - 25330445)

Ensembl ID

ENSG00000187010  (ver. 103.38)

Orthologs

-

UniProt

Q02161

neXtProt

NX_Q02161

Human splice variants

Protein structure