PROKR1

This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]

Description

Prokineticin receptor 1

Tissue specificity

Tissue enhanced (adipose tissue, epididymis)

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

2 (68643579 - 68658251)

Ensembl ID

ENSG00000169618  (ver. 103.38)

Orthologs

-

UniProt

Q8TCW9

neXtProt

NX_Q8TCW9

Human splice variants

Protein structure