KCNS3

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

Description

Potassium voltage-gated channel modifier subfamily S member 3

Tissue specificity

Tissue enhanced (skeletal muscle, tongue)

Subcell location

Golgi apparatus, Plasma membrane, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Chromosome

2 (17877847 - 18361616)

Ensembl ID

ENSG00000170745  (ver. 103.38)

Orthologs

Mouse Kcns3: ENSMUSG00000043673

UniProt

Q9BQ31

neXtProt

NX_Q9BQ31

Human splice variants
Mouse splice variants

Protein structure