Tissue expression
Cell line expression
Protein structure
RASA4
RAS p21 protein activator 4CAPRI, GAPL, KIAA0538
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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antibodies-online | ABIN2033965 | Polyclonal |
WB
ICC |
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GeneTex | GTX121563 | Polyclonal |
WB
ICC |
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Invitrogen Antibodies | PA5-31885 | Polyclonal |
WB
ICC |
||
Novus Biologicals | NBP2-15089 | Polyclonal |
WB
ICC |
||
Abbkine Scientific Co.Ltd. | ABP60100 | Polyclonal |
WB
EL |
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