PLEKHA4

This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

Description

Pleckstrin homology domain containing A4

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane, Cytokinetic bridge, Centriolar satellite, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

19 (48837097 - 48868617)

Ensembl ID

ENSG00000105559  (ver. 103.38)

Orthologs

Mouse Plekha4: ENSMUSG00000040428

UniProt

Q9H4M7

neXtProt

NX_Q9H4M7

Human splice variants
Mouse splice variants

Protein structure