GALNT9

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. This gene is expressed specifically in the brain, with highest expression in the cerebellum. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Polypeptide N-acetylgalactosaminyltransferase 9

Tissue specificity

Tissue enhanced (brain, thyroid gland)

Subcell location

Vesicles

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

12 (132196372 - 132329589)

Ensembl ID

ENSG00000182870  (ver. 103.38)

Orthologs

Mouse Galnt9: ENSMUSG00000033316

UniProt

Q9HCQ5

neXtProt

NX_Q9HCQ5

Human splice variants
Mouse splice variants

Protein structure