IL4I1

This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macrophages and dendritic cells. This protein may play a role immune system escape as it is expressed in tumor-associated macrophages and suppresses T-cell responses. This protein also contains domains thought to be involved in the binding of flavin adenine dinucleotide (FAD) cofactor. Multiple transcript variants encoding different isoforms have been found for this gene. Some transcripts of this gene share a promoter and exons of the 5' UTR with the overlapping NUP62 gene. [provided by RefSeq, Jul 2020]

Description

Interleukin 4 induced 1

Tissue specificity

Group enriched (lymphoid tissue, testis)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Secreted to blood

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (49889654 - 49929539)

Ensembl ID

ENSG00000104951  (ver. 103.38)

Orthologs

Mouse Il4i1: ENSMUSG00000074141

UniProt

Q96RQ9

neXtProt

NX_Q96RQ9

Human splice variants
Mouse splice variants

Protein structure