DMBT1

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016]

Description

Deleted in malignant brain tumors 1

Tissue specificity

Group enriched (intestine, salivary gland)

Subcell location

Centriolar satellite

Predicted location

Intracellular, Secreted in other tissues

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (122560665 - 122643736)

Ensembl ID

ENSG00000187908  (ver. 103.38)

Orthologs

Mouse Dmbt1: ENSMUSG00000047517

UniProt

Q9UGM3

neXtProt

NX_Q9UGM3

Human splice variants
Mouse splice variants

Protein structure