ADAMTS8

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016]

Description

ADAM metallopeptidase with thrombospondin type 1 motif 8

Tissue specificity

Tissue enhanced (lung)

Predicted location

Secreted to extracellular matrix

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins

Chromosome

11 (130404923 - 130428609)

Ensembl ID

ENSG00000134917  (ver. 103.38)

Orthologs

Mouse Adamts8: ENSMUSG00000031994

UniProt

Q9UP79

neXtProt

NX_Q9UP79

Human splice variants
Mouse splice variants

Protein structure