LHX8

The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Description

LIM homeobox 8

Tissue specificity

Tissue enhanced (brain, lymphoid tissue, salivary gland)

Subcell location

Nucleoplasm, Nucleoli, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

1 (75128434 - 75161533)

Ensembl ID

ENSG00000162624  (ver. 103.38)

Orthologs

Mouse Lhx8: ENSMUSG00000096225

UniProt

Q68G74

neXtProt

NX_Q68G74

Human splice variants
Mouse splice variants

Protein structure