CLCA2

This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016]

Description

Chloride channel accessory 2

Tissue specificity

Tissue enhanced (esophagus, skin , vagina)

Subcell location

Nucleoplasm, Plasma membrane, Cell Junctions

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (86424171 - 86456553)

Ensembl ID

ENSG00000137975  (ver. 103.38)

Orthologs

Mouse Clca2: ENSMUSG00000036960

UniProt

Q9UQC9

neXtProt

NX_Q9UQC9

Human splice variants
Mouse splice variants

Protein structure