PKP4

Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

Description

Plakophilin 4

Tissue specificity

Tissue enhanced (brain, choroid plexus)

Subcell location

Plasma membrane, Cell Junctions

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (158456952 - 158682879)

Ensembl ID

ENSG00000144283  (ver. 103.38)

Orthologs

Mouse Pkp4: ENSMUSG00000026991

UniProt

Q99569

neXtProt

NX_Q99569

Human splice variants
Mouse splice variants

Protein structure