ARFGAP3

The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]

Description

ADP ribosylation factor GTPase activating protein 3

Tissue specificity

Low tissue specificity

Subcell location

Golgi apparatus, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

22 (42796502 - 42858106)

Ensembl ID

ENSG00000242247  (ver. 103.38)

Orthologs

Mouse Arfgap3: ENSMUSG00000054277

UniProt

Q9NP61

neXtProt

NX_Q9NP61

Human splice variants
Mouse splice variants

Protein structure