Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
ALPP
Alkaline phosphatase, placentalPALP, PLAP
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Aug 2020]
Top validated antibodies |
|||||
| Novus Biologicals |  NB110-3638 |
13 references | Monoclonal |
WB
EL
ICC
IHC
FC
|
|
| Proteintech Group | 18507-1-AP |
5 references | Polyclonal |
WB
EL
IP
IHC
|
|
| Invitrogen Antibodies | 18507-1-AP |
Polyclonal |
WB
IP
IHC
FC
OA
|
||
| antibodies-online | ABIN258034 |
9 references | Monoclonal |
WB
EL
ICC
IHC
FC
|
|
| GeneTex | GTX72989 |
2 references | Polyclonal |
WB
IP
IHC
|
|
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider