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ARNT2
Aryl hydrocarbon receptor nuclear translocator 2bHLHe1, KIAA0307
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013]
Top validated antibodies |
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| Atlas Antibodies |  HPA001056 |
1 references | Polyclonal |
ICC
IHC
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| Proteintech Group | 12810-1-AP |
1 references | Polyclonal |
WB
EL
IHC
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| Santa Cruz Biotechnology | sc-5581 |
2 references | Polyclonal |
WB
IHC
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| LSBio | LS-C354133 |
Polyclonal |
WB
IHC
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| Novus Biologicals | NBP1-88623 |
1 references | Polyclonal |
ICC
IHC
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