CACNA1D

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Description

Calcium voltage-gated channel subunit alpha1 D

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nuclear membrane

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Chromosome

3 (53328963 - 53813733)

Ensembl ID

ENSG00000157388  (ver. 103.38)

Orthologs

Mouse Cacna1d: ENSMUSG00000015968

UniProt

Q01668

neXtProt

NX_Q01668

Human splice variants
Mouse splice variants

Protein structure