PSPN

This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma. [provided by RefSeq, Aug 2016]

Description

Persephin

Tissue specificity

Tissue enhanced (brain)

Predicted location

Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

19 (6375148 - 6379058)

Ensembl ID

ENSG00000125650  (ver. 103.38)

Orthologs

-

UniProt

O60542

neXtProt

NX_O60542

Human splice variants

Protein structure