ATP8A1

The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

ATPase phospholipid transporting 8A1

Tissue specificity

Tissue enhanced (brain)

Subcell location

Vesicles

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

4 (42408373 - 42657105)

Ensembl ID

ENSG00000124406  (ver. 103.38)

Orthologs

Mouse Atp8a1: ENSMUSG00000037685

UniProt

Q9Y2Q0

neXtProt

NX_Q9Y2Q0

Human splice variants
Mouse splice variants

Protein structure