CHCHD2

gene product
C7orf17, MIX17B, MNRR1
The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
145 antibodies from 27 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Proteintech Group
4 antibodies
Biorbyt
12 antibodies
antibodies-online
51 antibodies
NovoPro Bioscience Inc.
2 antibodies
Abnova Corporation
3 antibodies
Atlas Antibodies
2 antibodies
Abgent
1 antibody
Arigo
1 antibody
GeneTex
1 antibody
OriGene
1 antibody
Wuhan Fine Biotech Co., Ltd.
1 antibody
Invitrogen Antibodies
5 antibodies
Novus Biologicals
4 antibodies
LifeSpan BioSciences, Inc.
17 antibodies
Aviva Systems Biology
1 antibody
Cusabio Biotech Co., Ltd
1 antibody
St John's Laboratory
1 antibody
ProSci
1 antibody
Affinity Biosciences
1 antibody
MyBioSource
3 antibodies
United States Biological
13 antibodies
Leading Biology
1 antibody
MilliporeSigma / Merck KGaA
1 antibody
Creative Diagnostics
1 antibody
Abbexa
2 antibodies
Creative Biolabs
2 antibodies