GYPB

Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Description

Glycophorin B (MNS blood group)

Tissue specificity

Tissue enriched (bone marrow)

Predicted location

Intracellular, Membrane

Protein family

Blood group antigen proteins
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

4 (143996104 - 144019380)

Ensembl ID

ENSG00000250361  (ver. 103.38)

Orthologs

-

UniProt

P06028

neXtProt

NX_P06028

Human splice variants

Protein structure