TLR8

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

Description

Toll like receptor 8

Tissue specificity

Tissue enhanced (lung, lymphoid tissue)

Predicted location

Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

X (12906620 - 12923169)

Ensembl ID

ENSG00000101916  (ver. 103.38)

Orthologs

Mouse Tlr8: ENSMUSG00000040522

UniProt

Q9NR97

neXtProt

NX_Q9NR97

Human splice variants
Mouse splice variants

Protein structure