ITIH5

This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Description

Inter-alpha-trypsin inhibitor heavy chain 5

Tissue specificity

Tissue enhanced (adipose tissue)

Subcell location

Golgi apparatus, Vesicles

Predicted location

Intracellular, Secreted to blood

Protein family

Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (7559270 - 7666998)

Ensembl ID

ENSG00000123243  (ver. 103.38)

Orthologs

Mouse Itih5: ENSMUSG00000025780

UniProt

 

neXtProt

 

Human splice variants
Mouse splice variants

Protein structure