FBXL19

This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Description

F-box and leucine rich repeat protein 19

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (30923055 - 30948783)

Ensembl ID

ENSG00000099364  (ver. 103.38)

Orthologs

Mouse Fbxl19: ENSMUSG00000030811

UniProt

Q6PCT2

neXtProt

NX_Q6PCT2

Human splice variants
Mouse splice variants

Protein structure