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Protein structure
IQSEC2
IQ motif and Sec7 domain ArfGEF 2BRAG1, IQ-ArfGEF, KIAA0522, MRX1, MRX18, MRX78
This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Top validated antibodies |
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| GeneTex |  GTX32143 |
Polyclonal |
WB
EL
IHC
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| Boster Biological Technology | A09440 |
Polyclonal |
WB
EL
IHC
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| Invitrogen Antibodies | PA5-72831 |
Polyclonal |
WB
EL
IHC
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| OriGene | TA349113 |
Polyclonal |
WB
IHC
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| Proteintech Group | 25321-1-AP |
Polyclonal |
EL
IHC
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