Tissue expression
Cell line expression
Protein structure
TXNRD3
Thioredoxin reductase 3TGR, TR2, TR2IT1, TRXR3, TXNRD3IT1, TXNRD3NB, TXNRD3NT1
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. Experimental evidence suggests the use of a non-AUG (CUG) codon as a translation initiation codon (PMID:20018845). [provided by RefSeq, Aug 2017]
Top validated antibodies |
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Proteintech Group | 19517-1-AP | Polyclonal |
WB
EL
IHC
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NovoPro Bioscience Inc. | 116460 | Polyclonal |
WB
EL
IHC
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antibodies-online | ABIN1881963 | 2 references | Polyclonal |
WB
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Cusabio Biotech Co., Ltd | CSB-PA025390GA01HU | Polyclonal |
WB
EL
IHC
|
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Wuhan Fine Biotech Co., Ltd. | FNab09135 | Polyclonal |
WB
EL
IHC
|
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