RGS7BP

This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

Description

Regulator of G protein signaling 7 binding protein

Tissue specificity

Tissue enhanced (brain)

Subcell location

Plasma membrane, Actin filaments, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

5 (64506015 - 64612319)

Ensembl ID

ENSG00000186479  (ver. 103.38)

Orthologs

Mouse Rgs7bp: ENSMUSG00000021719

UniProt

Q6MZT1

neXtProt

NX_Q6MZT1

Human splice variants
Mouse splice variants

Protein structure