CLDN8

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. [provided by RefSeq, May 2010]

Description

Claudin 8

Tissue specificity

Tissue enhanced (breast, intestine, kidney, salivary gland)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

21 (30214006 - 30216097)

Ensembl ID

ENSG00000156284  (ver. 103.38)

Orthologs

Mouse Cldn8: ENSMUSG00000050520

UniProt

P56748

neXtProt

NX_P56748

Human splice variants
Mouse splice variants

Protein structure