UGT2B28

This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011]

Description

UDP glucuronosyltransferase family 2 member B28

Tissue specificity

Tissue enriched (breast)

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

4 (69280475 - 69295050)

Ensembl ID

ENSG00000135226  (ver. 103.38)

Orthologs

-

UniProt

Q9BY64

neXtProt

NX_Q9BY64

Human splice variants

Protein structure