OXT

This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]

Description

Oxytocin/neurophysin I prepropeptide

Tissue specificity

Tissue enriched (brain)

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins

Chromosome

20 (3071620 - 3072517)

Ensembl ID

ENSG00000101405  (ver. 103.38)

Orthologs

Mouse Oxt: ENSMUSG00000027301

UniProt

P01178

neXtProt

NX_P01178

Human splice variants
Mouse splice variants

Protein structure