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Protein structure
PLAT
Plasminogen activator, tissue typeThis gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Top validated antibodies |
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| Proteintech Group |  10147-1-AP |
13 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Novus Biologicals | NBP2-20648 |
3 references | Polyclonal |
WB
EL
IHC
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| Invitrogen Antibodies | 10147-1-AP |
Polyclonal |
WB
IP
IHC
OA
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| Boster Biological Technology | A02965-1 |
Polyclonal |
WB
ICC
IHC
FC
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| Santa Cruz Biotechnology | sc-15346 |
2 references | Polyclonal |
WB
IHC
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