678602

antibody from BioLegend
Targeting: FGF1 AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-alpha, FGFA, GLIO703, HBGF1
Provider product page for 678602

Antibody data

Product number
678602 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#678602, RRID:AB_2565906
Product name
Purified anti-FGF-1-acidic
Antibody type
Monoclonal
Antigen
Parital human human FGF-1 recombinant protein (16-155 a.a.) expressed in E. coli.
Description
FGF-1, one of the most studied members of the fibroblast growth factor family, is a powerful mitogen exhibiting strong action on many different cell types. FGF-1 activity can be mediated not only by autocrine/paracrine pathways, but also by an intracrine pathway. FGF-1 lacks a secretion signal peptide and is exported through a non-classical pathway. Endogenous FGF-1 is found in the nucleus of most cell types. Nuclear localization is required for FGF-1 mitogenic activity. FGF-1 promotes tumor development by promoting cancer cell proliferation and survival. Increased FGF-1 expression in early stages of many different cancers have been reported. MCF-7 breast cancer cell lines that overexpress FGF-1 can form vascularized, metastatic tumors when injected into ovariectomized or tamoxifen-treated nude mice. FGF-1 also induces angiogenesis in vitro and in vivo. Thus, FGF-1 is an attractive candidate for cancer immunotargeting. FGF-1 is also involved in neuronal cell differentiation and survival. FGF-1 is highly expressed in motor neurons. In response to damage, motor neurons can release FGF-1, which results in astrocyte activation. Under oxidative stress, astrocytes can also release FGF-1, which stimulates ApoE/HDL generation in an autocrine manner for protection of the brain against oxidative stress. The involvement of FGF-1 in inflammation, cardioprotection, wound healing, adipocyte remodeling, and restenosis have also been reported.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
11A5C44
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
FGF1 protein structure - 678602 shown in red.