Antibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 15122-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15122-1-AP, RRID:AB_2188778
- Product name
- SIRT5 antibody
- Antibody type
- Polyclonal
- Description
- SIRT5 antibody (Cat. #15122-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome.
Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Proteomic analysis of lysine acetylation reveals that metabolic enzymes and heat shock proteins may be potential targets for DSS-induced mice colitis.
SIRT4 is the molecular switch mediating cellular proliferation in colorectal cancer through GLS mediated activation of AKT/GSK3β/CyclinD1 pathway.
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy.
Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl-CoA acetyltransferase 1.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Lysine glutarylation in human sperm is associated with progressive motility.
SIRT5-mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer.
SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis.
SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice.
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Peoples JN, Ghazal N, Duong DM, Hardin KR, Manning JR, Seyfried NT, Faundez V, Kwong JQ
American journal of physiology. Cell physiology 2021 Sep 1;321(3):C519-C534
American journal of physiology. Cell physiology 2021 Sep 1;321(3):C519-C534
Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.
Qu H, Gong X, Liu X, Zhang R, Wang Y, Huang B, Zhang L, Zheng H, Zheng Y
Diabetes 2021 Jun;70(6):1372-1387
Diabetes 2021 Jun;70(6):1372-1387
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Cui W, Wu X, Shi Y, Guo W, Luo J, Liu H, Zheng L, Du Y, Wang P, Wang Q, Feng D, Ge S, Qu Y
Cell proliferation 2021 Feb;54(2):e12964
Cell proliferation 2021 Feb;54(2):e12964
Proteomic analysis of lysine acetylation reveals that metabolic enzymes and heat shock proteins may be potential targets for DSS-induced mice colitis.
Wang JM, Lin SR, Zhu YB, Yuan J, Wang YM, Zhang Q, Xie LS, Li SH, Liu SQ, Yu SG, Wu QF
International immunopharmacology 2021 Dec;101(Pt B):108336
International immunopharmacology 2021 Dec;101(Pt B):108336
SIRT4 is the molecular switch mediating cellular proliferation in colorectal cancer through GLS mediated activation of AKT/GSK3β/CyclinD1 pathway.
Cui Y, Bai Y, Yang J, Yao Y, Zhang C, Liu C, Shi J, Li Q, Zhang J, Lu X, Zhang Y
Carcinogenesis 2021 Apr 17;42(3):481-492
Carcinogenesis 2021 Apr 17;42(3):481-492
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
Li ST, Huang, Shen S, Cai Y, Xing S, Wu G, Jiang Z, Hao Y, Yuan M, Wang N, Zhu L, Yan R, Yang D, Wang L, Liu Z, Hu X, Zhou R, Qu K, Li A, Duan X, Zhang H, Gao P
Nature metabolism 2020 Mar;2(3):256-269
Nature metabolism 2020 Mar;2(3):256-269
Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy.
Ali HR, Michel CR, Lin YH, McKinsey TA, Jeong MY, Ambardekar AV, Cleveland JC, Reisdorph R, Reisdorph N, Woulfe KC, Fritz KS
Journal of molecular and cellular cardiology 2020 Jan;138:304-317
Journal of molecular and cellular cardiology 2020 Jan;138:304-317
Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl-CoA acetyltransferase 1.
Guan J, Jiang X, Gai J, Sun X, Zhao J, Li J, Li Y, Cheng M, Du T, Fu L, Li Q
Journal of cellular and molecular medicine 2020 Dec;24(23):14039-14049
Journal of cellular and molecular medicine 2020 Dec;24(23):14039-14049
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.
Sun X, Wang S, Li Q
Frontiers in genetics 2019;10:879
Frontiers in genetics 2019;10:879
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Fan X, Yan K, Meng Q, Sun R, Yang X, Yuan D, Li F, Deng H
International journal of molecular medicine 2019 Jul;44(1):157-171
International journal of molecular medicine 2019 Jul;44(1):157-171
Lysine glutarylation in human sperm is associated with progressive motility.
Cheng YM, Hu XN, Peng Z, Pan TT, Wang F, Chen HY, Chen WQ, Zhang Y, Zeng XH, Luo T
Human reproduction (Oxford, England) 2019 Jul 8;34(7):1186-1194
Human reproduction (Oxford, England) 2019 Jul 8;34(7):1186-1194
SIRT5-mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer.
Shi L, Yan H, An S, Shen M, Jia W, Zhang R, Zhao L, Huang G, Liu J
Molecular oncology 2019 Feb;13(2):358-375
Molecular oncology 2019 Feb;13(2):358-375
SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis.
Ma Y, Qi Y, Wang L, Zheng Z, Zhang Y, Zheng J
Free radical biology & medicine 2019 Apr;134:458-467
Free radical biology & medicine 2019 Apr;134:458-467
SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice.
Du Y, Hu H, Qu S, Wang J, Hua C, Zhang J, Wei P, He X, Hao J, Liu P, Yang F, Li T, Wei T
EBioMedicine 2018 Oct;36:347-357
EBioMedicine 2018 Oct;36:347-357
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Liu M, Liang K, Zhen J, Zhou M, Wang X, Wang Z, Wei X, Zhang Y, Sun Y, Zhou Z, Su H, Zhang C, Li N, Gao C, Peng J, Yi F
Nature communications 2017 Sep 4;8(1):413
Nature communications 2017 Sep 4;8(1):413
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- The SIRT5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIRT5. This antibody recognizes human, mouse, rat antigen. The SIRT5 antibody has been validated for the following applications: ELISA, WB analysis.