AFC-372CL

antibody from Creative Biolabs

Targeting: IGF2 C11orf43, FLJ44734, IGF-II

No application information provided.

Antibody Data

Product number

AFC-372CL

Provider

Creative Biolabs

Product name

Afuco? Anti-Human IGF2 ADCC Recombinant Antibody (DX-2647), ADCC Enhanced

Antibody type

Monoclonal

Description

Anti-IGF2 ADCC Enhanced Antibody (DX-2647) is an ADCC enhanced antibody produced by our Afuco? platform. This is a human monoclonal antibody against insulin-like growth factor-II that blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. DX-2647 inhibited IGF-II and, to a lesser extent, IGF-I-induced receptor tyrosine phosphorylation, cellular proliferation, and both anchorage-dependent and anchorage-independent colony formation in various cell lines. In addition, DX-2647 slowed tumor progression in the Hep3B xenograft model, causing decreased tumoral CD31 staining as well as reduced IGF-IIE and IGF-IR phosphorylation levels. Therefore, DX-2647 offers an alternative approach to targeting IGF-IR, blocking IGF-II signaling through both IGF-IR and IR-A.

Reactivity

Human

Storage

Store at 4¡ãC for up to 3 months. For longer term storage aliquot into small volumes and store at -20¡ãC.