BS6297

antibody from Bioworld Technology, Inc
Targeting: TPMT
Provider product page for BS6297
Western blot
Immunohistochemistry

Antibody data

Product number
BS6297 - Provider product page
Provider
Bioworld Technology, Inc
Product name
TPMT polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human TPMT.
Description
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency).TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
TPMT protein structure - BS6297 shown in red.